Medication

Hypothiazide

Structure

The tablet contains the main component Hydrochlorothiazide in an amount of 25/100 mg and additional substances in the form of gelatin, talc, magnesium stearate, starch from corn and lactose monohydrate.

Release form

Hydrochlorothiazide tablets are round, flat, white in color. The letter "H" is engraved on one side, and a dividing risk is located on the other side. The tablets are compactly packed in special blisters of 20 pieces. There is 1 blister in a pack, an instruction from the manufacturer with a detailed description of all sections is additionally attached.

Pharmachologic effect

Diuretic agent.The principle of thiazide diuretics is based on reinforcement diuresis by suppressing the reabsorption of Na and Cl ions in the initial sections of the tubules of the renal system, which causes increased excretion of Na, Cl and water ions. Excretion increases in parallel electrolytes (Mg, K, etc.).

The maximum therapeutic dosages of thiazide duretics give approximately the same natriuretic / diuretic effect. Diuresis and nitriuresis are recorded after 2 hours, and the maximum effect appears after 4 hours. Thiazide diuretics are able to suppress the activity of carbonic anhydrase due to increased excretion of bicarbonate ions. This effect is weakly expressed and has virtually no effect on urine pH. Hydrochlorothiazide is characteristic hypotensive effect. To normal blood pressure active substance has no effect.

Pharmacodynamics and pharmacokinetics

Suction, distribution

The active substance, although not complete, but is very quickly absorbed from the gastrointestinal tract (the effect lasts 6-12 hours). The maximum concentration is recorded after 1.5-2.5 hours when taking 100 mg of the active substance. With a concentration of hydrochlorothiazide in blood plasma 2 μg / ml, the most pronounced diuretic effect is observed (4 hours after taking the pill). The rate of protein binding is 40%. The active ingredient hydrochlorothiazide is able to pass into breast milk and can pass with ease. placental barrier.

Breeding

Unchanged, the active substance is excreted by the renal system throughfiltering and secretion. The indicator T1 2 with a normally functioning renal system is 6.4 hours.

Pharmacokinetics of a special category of patients

With CC less than 30 ml per minute, T1 / 2 (elimination half-life) is 20.7 hours. With moderate pathology of the renal system, this indicator is 11.5 hours.

Indications Hypothiazide

What are hypothiazide tablets from? The medication is prescribed for edematous syndrome of various genesis:

  • portal hypertension;
  • chronic renal failure;
  • nephrotic syndrome;
  • taking corticosteroids;
  • acute glomeruloneurfite;
  • premenstrual tension syndrome;
  • chronic heart failure.

Indications for use of hypothiazide:

  • control at polyuria (at diabetes insipidusat nephrogenic diabetes);
  • arterial hypertension (in combination with other antihypertensive drugs, in monotherapy);
  • prevention of stone formation in the urinary system in susceptible patients (risk reduction hypercalciuria).

Contraindications

The main contraindications to the appointment of hydrochlorothiazide:

  • Addison's disease;
  • severe hepatic insufficiency;
  • anuria;
  • severe renal failure;
  • difficult to control diabetes mellitus;
  • individual hypersensitivity;
  • age limit - up to three years (relevant for solid dosage form);
  • refractory hyponatremia (decrease in NA level), hypokalemia, hypercalcemia;
  • intolerance to sulfonamides.

Relative contraindications:

  • lactose intolerance;
  • hypokalemia;
  • cardiac glycoside intake (e.g. Digoxin);
  • gout;
  • cirrhotic damage to the hepatic system;
  • Ischemic heart disease;
  • hypercalcemia;
  • hyponatremia;
  • elderly age.

Side effects

Metabolism:

  • hyponatremia;
  • hypercalcemia;
  • hypokalemia;
  • hypochloremic alkalosis;
  • glucosuria;
  • hyperglycemia;
  • hyperuricemia
  • hypomagnesemia.

Hypnotatremia manifests itself muscle crampsfatigue, convulsions, confusion, excessive excitability, lethargy. At hypochloremic alkalosis nausea, weakness, vomiting, muscle pain and cramps, various options are noted heart rhythm disturbances, thirst, dry mouth, changes in psyche and mood. Against the background of hypochloremic alkalosis, it can develop hepatic encephalopathy (up to hepatic coma) A decrease in sugar tolerance can cause exacerbation, a manifestation of the latent form of diabetes mellitus, which is manifested in a biochemical analysis hyperglycemia.

Digestive tract:

  • constipation
  • anorexia;
  • cholestatic jaundice;
  • cholecystitis;
  • diarrheal syndrome;
  • pancreatitis
  • sialadenitis.

The cardiovascular system:

  • arrhythmia;
  • vasculitis;
  • orthostatic hypotension.

Peripheral nervous system, CNS:

  • headache;
  • temporary blurred visual perception;
  • dizziness;
  • paresthesia.

Allergic answers:

  • respiratory distress syndrome (edema light non-cardiogenic genesis, pneumonitis).

Other negative reactions:

  • development interstitial jade;
  • changes in the functioning of the renal system;
  • potency disorder.

Hypothiazide tablets, instructions for use (method and dosage)

The medicine is intended for use per os. Dose selection is carried out individually. The determination of the minimum effective dosage is carried out with constant medical supervision. The increased loss of Mg and K ions during the administration of hydrochlorothiazide requires ion substitution.

Instructions for use of hypothiazide in adults to lower blood pressure

Therapy begins with minimum dosages of 25-50 mg once a day. Allowed as a combination with other antihypertensive drugs, and monotherapy. 12.5 mg of hypothiazide is sufficient for some patients. The antihypertensive effect manifests itself after 3-4 days, but the optimal therapeutic effect is recorded only after 3-4 weeks. At the end of therapy, the hypotensive effect of the drug persists for a week.

Relief of puffiness

Therapy of edematous syndrome begins with 25-100 mg of hypothiazide (1 time in 2 days is allowed). In severe cases, 200 mg per day is required. At premenstrual syndrome25 mg per day are prescribed from the onset of negative symptoms and until the onset of menstruation.

With the nephrogenic form of diabetes insipidus, 50-150 mg of the drug is prescribed per day in several doses.

For children, the dose is calculated by weight. The average pediatric dosage is 1-2 mg / kg or 30-60 mg / m2 of the child’s body surface (per 1 dose). The daily dose for children 3-12 years old is 37.5-100 mg.

Overdose

The clinical picture of overdose manifests itself due to a sharp loss electrolytes and fluid, which is manifested by the following symptoms:

  • paresthesia;
  • dizziness;
  • drop in blood pressure;
  • spasms in the calf muscles;
  • hypokalemia;
  • alkalosis;
  • hypochloremia;
  • confusion of consciousness;
  • severe weakness, apathy;
  • tachycardia;
  • oliguria;
  • increase in concentration urea nitrogen (more pronounced in patients with pathology of the renal system);
  • hyponatremia;
  • anuria (as a result of blood concentration);
  • polyuria;
  • nausea;
  • shock;
  • vomiting

Recommended artificial induction of vomiting, gastric lavage, appointment Activated carbon or other drugs with an enterosorbing effect. With shock and a drop in blood pressure, measures are taken to reimburse the volume of circulating blood and electrolytes (Na, K). Mandatory monitoring of status indicators water-electrolyte balance(special attention is paid to the level of potassium in the blood), on the work of the renal system (until the normalization of all indicators). Specific antidote not developed.

Interaction

Taking antihypertensive drugs may require correction of the dosage regimen of hypothiazide, as drugs are able to potentiate each other's action. An increase in lithium toxicity and decrease in renal clearance in treatment lithium salts. Hypomagnesemia and hypokalemia arising from the use of diuretics can enhance the toxic effects of digitalis, which must be taken into account when taking Digoxin and other cardiac glycosides. The risk of developing arrhythmias associated with hypokalemia increases significantly when taken Amiodarone. Hyperglycemia and a decrease in the effectiveness of oral forms are recorded hypoglycemic drugs while taking Hypothiazide. The excretion of potassium is enhanced when taken corticosteroid drugs. NSAIDs can reduce the effectiveness of diuretics and inhibit the hypotensive effect of thiazides. Efficiency enhancement possible muscle relaxants(non-depolarizing forms). Antihypertensive orthostatic effect significantly enhanced when applied barbiturates, Ethanol, opioid analgesics. Colestyramine able to reduce the absorption of hypothiazide. Risk of toxic effects Amantadina increases because Hydrochlorothiazide reduces its clearance, increasing the concentration of amantadine in blood plasma. A temporary discontinuation of a thiazide diuretic is required before analyzes that characterize the functional state of the parathyroid glands.

Terms of sale

Presentation of a prescription medical form is required, indicating the active substance, an INN medication.

Recipe in Latin:
Tab. Hypothiazid (Hydrochlorothiazide) 25 mg
D.t.d. N20
S. 1 tablet per day.

Storage conditions

Tablets remain effective when stored in the original packaging at temperatures up to 25 degrees. Direct sunlight adversely affects the effectiveness of the drug and significantly reduces the shelf life specified by the manufacturer.

Shelf life

60 months.

Special instructions

Course, long-term diuretic therapy requires regular monitoring of indicators characterizing the state of water-electrolyte balance. At risk are patients with the following pathologies:

  • diseases of the cardiovascular system;
  • violations in the work of the liver system;
  • changes in water-electrolyte balance (muscle weakness, dry mouth, muscle pain, lethargy, thirst, oliguria, hypotension, tachycardia, convulsions, anxiety, drowsinessdisorders of the digestive tract).

It is possible to avoid hypokalemia when taking special potassium-sparing medicines and compliance diets with the use of foods rich in potassium (vegetables, fruits). Often, enhanced excretion of magnesium by the renal system during treatment with thiazide diuretics is recorded. Pathology of the renal system requires mandatory monitoring of clearance creatinine. In susceptible patients may be observed cumulative effect and develop azotemia. With oliguria, the option of canceling hypothiazide is considered.

With pathology of the hepatic system, a thiazide diuretic is prescribed with caution, because even slight fluctuations in the water-electrolyte balance can affect the level ammonium at blood and provoke a hepatic coma. Hypothiazide may cause increased bilirubin in blood. With severe coronary and cerebral sclerosis more careful attention to the patient's condition is required.

Taking thiazide medications affects glucose tolerance. In case of latent and manifest forms of diabetes mellitus against the background of prolonged diuretic therapy, control over indicators may be required metabolism carbohydrates, which is explained by the need to adjust the dosage of hypoglycemic drugs. Patients Suffering metabolism uric acidrequire special observation. Rarely, with prolonged use of the hypothiazide diuretic, changes in the work of the parathyroid glands are recorded, which is accompanied by hypophosphatemia and hypercalcemia. Thiazide forms of diuretics can reduce the level of iodine element, which is able to bind to proteins in serum, without affecting the functioning of the thyroid gland. In patients with glucose intolerance, complaints of the digestive tract are often recorded. The medication affects the ability to drive a motor vehicle and perform various types of work that may require increased attention from the patient.

Hypothiazide Analogs

Matches for ATX Level 4 code:DichlothiazideHydrochlorothiazide

Structural analogues:

      • Hydrochlorothiazide-ATS;
      • Hydrochlorothiazide.

Medicines with a similar pharmacological effect (diuretics):

      • Veroshpiron;
      • Diuver;
      • Indapamide;
      • Torasemide;
      • Arifon;
      • Spironolactone;
      • Inspra;
      • Lasix;
      • Furosemide.

Hypothiazide during pregnancy (and lactation)

The active ingredient hydrochlorothiazide is contraindicated in of pregnancy in the first trimester. It is allowed to prescribe a medication in the 2nd and 3rd trimesters in cases where the possible benefits for the mother significantly exceed the expected risk to the health of the fetus. The active substance can pass through the placental barrier. Newborns may develop thrombocytopenia, jaundice and other consequences. The active component is released when lactation, which may require interruption of breastfeeding if necessary, taking a diuretic.

Hypothiazide Reviews

The medication is often prescribed for diseases of the heart and vascular system, accompanied by edema syndrome. Patients note a mild diuretic effect of the drug in compliance with the dosages indicated by the doctor. Edematous syndrome stops gradually, without washing out the necessary trace elements from the body.

Reviews of hypothiazide for weight loss are mixed. Weight is really reduced, but only due to lost fluid. Kilograms return after water enters the body. The medication does not have any effect on adipose and muscle tissue, therefore the use of Hypothiazide for weight loss is impractical, and in some cases can harm health (loss of trace elements, dehydration, etc.)

Hypothiazide price, where to buy

The cost of the medication is relatively low and varies in small ranges depending on the amount of active substance, pharmacy network, region. The average price of hypothiazide in Russia is 100 rubles.

  • Online Pharmacies in Russia
  • Online pharmacies in UkraineUkraine
  • Online pharmacies in Kazakhstan

ZdravCity

  • Hypothiazide tab. 100mg n20Chinoin116 rub.order
  • Hypothiazide tab. 25mg n20Chinoin92 rub order

Pharmacy Dialog

  • Hypothiazide tablets 25mg No. 2090 rub. Order
  • Hypothiazide tablets 100mg No. 20103 rub.order

Eurofarm * 4% discount on the promotional code medside11

  • Hypothiazide 25 mg n20 tabHinoin pharmaceutical plant pr92 rub.order
show more

Pharmacy24

  • Hypothiazide 25mg N20 tablets Хіної Factory of Pharmaceutical and Chemical Products Privet Co. Ltd., Ugorshchina48 UAH order
  • Hypothiazide 100 mg No. 20 tablets Хіної Factory of Pharmaceutical and Chemical products PRIVATE Co., Ltd., Ugorshchina75 UAH order

Pani Pharmacy

  • Hypothiazide tablets Hypothiazide tablets 100mg №20 Hungary, Chinoin 93 UAH order
  • Hypothiazide tablets Hypothiazide tablets 25mg No. 20 Hungary, Chinoin 53 UAH order
show more

BIOSPHERE

  • Hypothiazide 25 mg No. 20 tablets Chinoin (Hungary) 1 tg.
  • Hypothiazide 100 mg No. 20 tablets Chinoin (Hungary) 1 tg.
show more

Popular Posts

Category Medication, Next Article

Ibandronic acid
Medication

Ibandronic acid

Composition Consists of ibandronic acid. Release form A powder of white or whitish color, which is easily soluble in water and practically insoluble in organic solvents. Also available in tablet form. Pharmacological action It is a nitrogen-containing bisphosphonate and an inhibitor of bone resorption.
Read More
Abomin
Medication

Abomin

Composition The active substance is rennet. Excipients: calcium stearate and potato starch. Release form The drug is available in tablet form. Pharmacological action Enzymatic agent, proteolytic enzyme. Abomin acts on milk, food proteins.
Read More
Ximelin Eco
Medication

Ximelin Eco

Composition Xymelin Eco contains the main substance: xylometazoline hydrochloride. Additional components: sodium hydrogen phosphate dihydrate and dihydrogen phosphate dihydrate, sodium chloride, disodium edetate and purified water. Release form Ximelin Eco is produced in the form of a nasal spray, with an active substance concentration of 0.05%.
Read More
Sodium Oxybutyrate
Medication

Sodium Oxybutyrate

Composition The preparation contains the active component of sodium oxybutyrate. Release form Sodium Oxybutyrate is produced in the form of a crystalline powder of a light color. The substance is highly soluble in water and ethanol. The medicine is packaged in bottles. Pharmacological action This drug has anesthetic, hypnotic, antihypoxic and anxiolytic effects.
Read More