Primidon, potato starch, sodium starch glycolate, erases calcium, polyvinylpyrrolidone.

Release form

Tablets 125 and 250 mg flat cylindrical white in contour packaging in a cardboard box No. 10, 20, 50.

Pharmachologic effect


Pharmacodynamics and pharmacokinetics


The drug reduces the excitability of neurons in the epileptogenic focus of the brain, reduces the number of large epileptic seizures, and has a weak hypnotic effect. The chemical structure of the drug is close to phenobarbital, but it has a more pronounced anticonvulsant effect, with a general inhibitory effect on CNS does not render.


The drug is completely and rapidly absorbed from Gastrointestinal tract. Max reached after 2 hours. The bioavailability of the drug is more than 90%. Primidon biotransformed in the liver, resulting in the formation of 2 pharmacologically active metabolites: phenylethyl malonamide and phenobarbital. Primidone and derivative metabolites are excreted in breast milk. It is excreted in the urine.

Indications for use

Treatmentepilepsy of various genesis with predominantly large convulsive seizures.


High sensitivity to the drug, kidney / liver disease, leukopenia, anemia, pregnancylactation.

Take with caution for elderly and children due to the high risk of motor and paradoxical arousal.

Side effects

Headache, drowsinessanxiety dizzinessapathy psychotic reactions, ataxiavomiting, nausea, leukopenia, B12 deficiency anemia, arthralgiaallergic reactions. With prolonged use - the development of drug dependence.

Hexamidine, instructions for use (Method and dosage)

Take after a meal, once in a single dose of 125 mg, then the daily dose is increased every 3 days by 250 mg for adults and 125 mg for children under 9 years of age. Take until a therapeutic effect is achieved. For adults, the maximum daily dose is 1.5 g (in 2 divided doses), for children - 1 g.


Inhibition of function CNS, ataxianausea dizziness.


The drug accelerates metabolism and weakens the pharmacological effect. paracetamolindirect anticoagulants GKS, tricyclic antidepressants, digitalis glycosides, caffeine, chloramphenicol, cyclosporine, disopyramid, doxycycline, dacarbazine, levothyroxine, mexiletine, metronidazole, quinidine, vitamin D, phenoprofen, aminophylline, theophylline, okstryfillina.

When taken together with alcohol, drugs with a central depressive effect intensifies depression CNS. Enhances the effect of drugs with sleeping pills, derivatives methotrexate, cyclophosphamide, sulfonylureas, as well as toxic effects on the liver of a group of drugs used for general anesthesia (methoxyflurane, halotana, enflurana) In conjunction with carbonic anhydrase inhibitors high risk of process disruption osteogenesis. The drug reduces antifungal activity griseofulvin.

Methylphenidate inhibits the metabolism of Primidon. Leucovorin weakens the anticonvulsant effect of the drug. In conjunction with Phenylbutazone - the pharmacological effect of the two drugs is mutually weakened. Myelotoxic drugs increase hematotoxicity of Primidon. When taken together with drugs that stimulate microsomal enzymatic activity of the liver: rifampicin, phenobarbitalethanol (with prolonged use), carbamazepine, Primidon's metabolism is accelerated and its pharmacological effectiveness decreases.

Terms of sale

On prescription.

Storage conditionsMilepsin

Shelf life

60 months.

Hexamidine Analogs

Matches for ATX Level 4 code:PrimidonBenzonalPhenobarbital

Primidon, Misolin, Misolin, Primaklon, Sertan, Deoxyphenobarbitone, Lepidine, Lespiral, Liscanthin, Misodin, Milepsin, Prilepsin, Primolin, Priozolin, Cedilen and others.

Reviews on hexamidine

According to doctors, Hexamidine is an effective anticonvulsant, especially in cases of generalized tonic-clonic seizures. The drug can be used both as a mono drug, and in combination with other drugs (diphenin, phenobarbital, clonazepam).

Hexamidine price, where to buy

The price of Hexamidine 250 mg tablets No. 50 varies from 485 to 728 rubles per pack. You can buy Hexamidine in most pharmacies in Moscow only by reservation or you will be offered one of its analogues.

Watch the video: Hexomėdine الدواء الفعال لحب الشباب (March 2020).

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