Nazol Advance


Oxymetazoline hydrochloride 0.05 g per 100 ml and excipients, including camphor, eucalyptol, levomenthol.

Release form

Spray for the nose 0.05% in 15, 10, 30 ml in a bottle.

Pharmachologic effect

The drug has local vasoconstrictorand decongestantact.

Pharmacodynamics and pharmacokinetics


Oxymetazolinebeing alpha2-adrenergic agonistrenders vasoconstrictor effect. As a result, vascular permeability decreases, which entails a decrease in swelling of the mucous membrane and facilitation of nasal breathing. Increased drainage of the sinuses due to the opening of their mouths. Camphor, Menthol and eucalyptolpossess anti-inflammatory, antiseptic, bactericidal and fungicidal action, normalize the secretion of the mucosa, improve mucus discharge.


When applied topically, the drug does not enter the bloodstream (systemic absorption). Menthol, camphor and eucalyptol penetrate into the systemic circulation in small doses, from where they are excreted through the lungs. The drug begins to act in 10-15 minutes and its effect lasts 10-12 hours. Symptoms disappear rhinitis 3-4 days after the start of treatment.

Indications for use

Nazol Advance is used for symptomatic treatment:

  • acute rhinitis any etiology;
  • acute sinusitis, sinusitis, frontal sinusitis.

The drug is used to eliminate swelling of the mucous membrane during operations in the nose and after surgery.


  • atrophic rhinitis;
  • thyroid disease;
  • carbohydrate metabolism disorders;
  • pregnancy and period lactation;
  • age up to 6 years;
  • hypersensitivity to the drug.

Caution prescribed for arterial hypertension, arrhythmias, renal failure, angle-closure glaucoma, prostatic hyperplasia.

Side effects

Side effects are possible with prolonged use and when exceeding the recommended doses.

Local reaction manifests itself burning, tingling in the nose.

Systemic reactions when using the drug for more than 3 days: nausea, fatigue, sweating, dizziness, palpitations, agitation and sleep disturbance.

Instructions for use Nazol Advance (Method and dosage)

The drug is used intranasally. In order to avoid side effects, the instruction should be strictly observed.

The nasal passages are cleaned before using the drug. The bottle is placed in the nasal passage with the nebulizer up and is strongly compressed during inhalation through the nose. Another nasal passage at this time is closed. Injection is performed in both nasal passages.

Adults and children over 12 years of age: 2 doses 2 times a day with an interval of 12 hours. The course of treatment is 3 days if the drug is used without a doctor's prescription.

Children from 6 to 12 years: 1 dose 2 times with an interval of at least 12 hours. The course of treatment is 3 days if the drug is used without a doctor's prescription.

If after 3 days the swelling of the mucous membrane persists, you need to consult a doctor who will determine the duration of the course of treatment depending on the severity of the disease. In order to prevent the spread of infection, the use of an individual vial for each patient is recommended.


Subject to recommendations, the use of Nazol Advance is not accompanied by an overdose. When using high doses oxymetazolineare possible ventricular extrasystole, short-term attacks of ventricular tachycardia, increased blood pressure, sleep disturbances and excessive excitability.


The drug is not recommended for use simultaneously with other vasoconstrictors. Do not appoint also at the same time monoamine oxidase inhibitors (procarbazine, selegin), which enhance the vasoconstrictor effect. Patients can use the drug 2 weeks after the end of taking MAO inhibitors.

Terms of sale

OTC vacation.

Storage conditions

Keep in a dry place, protecting from sunlight. Storage temperature not higher than 30 ° C.

Shelf life

Shelf life is 2 years.


Matches for ATX Level 4 code:Ximelin EcoXimelinNazivinGalazolinLazorinNazivin Sensitive for childrenOtrivinNaphthyzineSanorinKnoxprayForLazolvan RenoAfrinRinorusEvkazolin AquaRinazolinInfluenza RinoFarmazolinXylometazolineNazol Baby


Reviews about Nazol Advance

Most often, reviews about the drug are positive. Patients note quick action and effective help with difficulty in nasal breathing. It is important that the effect lasts a long time and it is enough to use the spray twice a day.

Many say that arises irritation and burning in the nasal passages after using the drug, however, these phenomena pass quickly and during the next use are not so pronounced. Isolated cases were noted. allergic reaction, which was manifested by profuse discharge from the nose and lacrimation. The patient’s complaints are also caused by the spray bottle - it is difficult to compress it strongly (due to the hardness of the material from which it is made) and to perform high-quality injection.

Price Nazol Advance, where to buy

The cost of the drug depends on the manufacturer and the capacity of the bottle. The drug is on sale in any pharmacy. In pharmacies in Moscow, the cost of Nazol Advance in bottles of 15 ml from 136 rubles. up to 152 rubles., in bottles of 30 ml - from 210 rubles. up to 248 rub.

  • Online Pharmacies in Russia
  • Online pharmacies in UkraineUkraine
  • Online pharmacies in Kazakhstan


  • Nazol Advance Spray doses. 0.025mg / dose 10ml Institute de Angeli S.R.L. 203 rub.order

Pharmacy Dialog

  • Nazol Advance (spray 0.025mg / dose 10ml) 198 rub.

Eurofarm * 4% discount on the promotional code medside11

  • Nazol Advance Nasal Spray 0.025 mg / dose 10 ml (150 doses) Institute de Angeli S.R.L. (Bayer230 rub.order
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  • Nazol Advance 0.05% 10 ml spray Istituto de Angeli S.r.l., Italy 63 UAH.order

Pani Pharmacy

  • Nazol Advance Liquid Nazol Advance Naz. spray 10ml Italy, Instituto de Angeli 75 UAH order
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  • Nazol Advance 15ml Spray named Sagmel, Inc. (Italy) 690 tg.order
  • Nazol Advance 10 ml spray named after Instituto De Angeli S.r.l. (Italy) 980 tg.order
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