The composition of Valz N includes valsartan and hydrochlorothiazide (active substances), as well as microcrystalline cellulose, lactose monohydrate, povidone K29-32, croscarmellose sodium, magnesium stearate, talc, colloidal silicon dioxide (additional substances).
Valz N is produced in the form of tablets (80 mg and 12.5 mg) of a biconvex form, which are covered with a pink film membrane. On one side of the tablet there is a marking "V", on the other - "H".
Valz N tablets in a dosage of 160 mg and 12.5 mg look similar, but have a reddish-brown color. Valz N tablets at a dosage of 160 mg and 25 mg look similar, but have an orange color.
Tablets are placed in blisters of 7 pieces, which are packed in a cardboard box.
Valz N is a combination type drug that has an antihypertensive effect on the body. It includes an angiotensin II receptor blocker and a thiazide diuretic.
Substance valsartan is a peripheral vasodilator, it acts on the body as a hypotensive agent and diuretic. Valsartan is a specific blocker of AT1 angiotensin II receptors; it does not inhibit ACE. The substance has no effect on the level of cholesterolglucose TG, uric acid. With a decrease in pressure in humans, there is no change in heart rate.
Substance hydrochlorothiazide is a medium power diuretic. Compared with furosemide, its diuretic effect is weaker. Under the influence of this substance, the excretion of potassium in the urine increases, as well as the excretion of bicarbonates and phosphates.
Hydrochlorothiazide increases excretion magnesium, in the body under its influence are delayed calcium ions and urata. Arterial pressure decreases due to a decrease in bcc, a change in the reactivity of the vessel wall, an increase in the level of depressive effects on the ganglia and a decrease in the decrease in the pressor effect of substances with vasoconstrictor properties.
Pharmacodynamics and pharmacokinetics
The simultaneous use of hydrochlorothiazide and valsartan reduces systemic bioavailability by approximately 30%. This interaction does not affect the overall effectiveness of the use of substances in combination.
Valsartan is rapidly absorbed, absorbed variable. Its bioavailability is 23%. The highest concentration of a substance is observed two hours after the use of drugs. Valsartan binds to blood proteins by 94-97%. Its half-life is 9 hours. Most of it is excreted unchanged, 70% through the intestines, 30% through the kidneys.
Hydrochlorothiazide after oral administration it is absorbed quickly, its bioavailability is 60-80%. The highest concentration of the substance is achieved after 2-5 hours. With plasma proteins hydrochlorothiazide binds to 60-80%. Its half-life is from 6 to 15 hours. It is excreted through the kidneys, while more than 95% comes out unchanged.
The greatest hypotensive effect in the treatment with the drug is observed in the first two to four weeks of therapy.
Indications for use
The drug Valz N is prescribed for the purpose of treatment arterial hypertension. It is prescribed to patients, provided that monotherapy valsartannot effective enough. Also, the drug is prescribed to reduce the risk of developing cardiovascular diseases in people suffering left ventricular hypertrophy and those who suffer arterial hypertension.
You can not use Valz N for treatment if a person has the following conditions and diseases:
- high sensitivity to the components of the product;
- bile duct obstruction;
- biliary cirrhosis;
- state hypercalcemia, hyponatremia, hyperuricemia, hypokalemia;
- pregnancy and breastfeeding.
Caution should be given when renal artery stenosis.
When treating with Valz N, a number of side effects can be noted, in particular:
- feeling tired dizziness;
- nausea, diarrhea;
- symptoms pharyngitisrhinitis;
- viral infections;
- hypercreatininemia, hyperkalemia;
- chest pain
- allergic manifestations;
- impaired kidney function.
In addition, potential negative reactions when using valsartan are insomnia, edema, asthenia, decreased sexual desire. Hydrochlorothiazide can provoke manifestations of a disorder of water-electrolyte balance, decreased appetite, urticaria, decreased potency.
Instructions for use Valz N (Method and dosage)
Take the drug orally, regardless of the meal. The tablet should be drunk abundantly. Initially, the patient is prescribed one tablet (80 mg and 12.5 mg) per day, then Valz N 160 mg is prescribed if necessary. People who have impaired renal function, in the absence of cholestasis, do not need to adjust the dose of Valz N.
With an overdose of the drug, a marked decrease in blood pressure can be noted.
In this case, an immediate gastric lavage is carried out, a 0.9% sodium chloride solution is administered intravenously to the patient. Hemodialysis is effective only with respect to hydrochlorothiazide.
With simultaneous therapy, the level of neurotoxicity of salicylates increases, side effects of cardiac glycosides, the neurotoxic and cardiotoxic effect of lithium preparations increase. The effectiveness of exposure to curariform muscle relaxants also increases.
Valz N lowers excretion quinidine.
With simultaneous treatment, the effectiveness of hypoglycemic oral drugs, anti-gout drugs, epinephrine, norepinephrine.
The frequency of development of allergic manifestations to allopurinol.
Valz N reduces the level of excretion of cytotoxic drugs through the kidneys and increases their myelosuppressive effect.
Drugs that intensively bind to blood proteins in the body (clofibrate, indirect anticoagulants, NSAIDs), increase the diuretic effect.
An increase in the hypotensive effect is noted while taking barbiturates, vasodilators, phenothiazines, beta-blockers, ethanol, tricyclic antidepressants.
Simultaneous administration of Valz N and methyldopa can provoke hemolysis.
Terms of sale
Valz N can be obtained by prescription.
The product must be stored in a place protected from children's access, where the temperature does not exceed 30 ° C.
You can store Valz N for 3 years.
Before prescribing a course of treatment, a correction is made of the level of sodium in the blood, BCC.
It is important to monitor the level of uric acid, potassium, lipids, glucose, plasma creatinine.
If pregnancy is detected, the course of treatment is immediately suspended.
During therapy, it is sometimes necessary to adjust the dose of insulin or other hypoglycemic agents.
There is evidence that thiazide diuretics can trigger an exacerbation in a person who is sick systemic lupus erythematosus.
During treatment, it should be borne in mind that Valz N can affect the level of concentration and the speed of psychomotor reactions.
Analogs Valz NMatches for ATX Level 4 code:DiocorGizaarTeveten PlusAtacand PlusKo diovanMikardis PlusVasar NLorista N / N
The following medicines are analogues of Valz N drug: Valsacor N, Atacand Plus, Vasotens N, Losartan n, Lorista N, Presartan N, Candecor n, Lakea N and etc.
Valz N is not used to treat children and adolescents under 18 years of age.
Under the influence of alcohol, the hypotensive effect of Valz N is enhanced.
During pregnancy and lactation
You can not take Valz N during pregnancy, as well as in the months of breastfeeding.
Reviews about Valz N
Reviews on Valz N 80 mg in the network, patients leave mostly positive. In particular, it is noted that Valz N, when taken regularly, effectively lowers blood pressure and allows you to achieve lasting results. On the side effects that occur as a result of taking the medicine, reviews are rarely noted.
Price Valz N, where to buy
Depending on the dosage, the price of Valz N is from 270 to 350 rubles per pack of 28 pcs. The cost of packaging Valz N 98 pcs. equals from 700 to 870 rubles.